Don't really think about it, I'd say i'm probably 70% NOBO, and 30% SOBO. Did the Wilderness SOBO in June one year. Did Dickey Gap back to Damascus another year, but other than that I've gone almost entirely NOBO...just happens to be the way it works out for shuttles, etc. I really don't have a preference, although my favorite so far has been both my SOBO hikes.