I wore them on my section hikes up to about 3 years ago when I switched to mesh hiking boots. I think the "waterproof" boots I've used over the years kept my feet too warm and damp, and the toebox(es) might not have been wide enough.
My biggest issue with the Injinji toe socks was that they were tough to get dry. Since my problem centered on only one or two toes, I found that putting a
gel-filled toe protector on the offending toe worked quite well, at least for a few weeks. I haven't had toe problems since I switched to mesh boots (plus my boots dry out a whole lot faster than my "waterproof" boots ever did).