Some people may find the small savings gained by refilling canisters justified. For most of us, I'd have to argue that the risks, no matter how small, just aren't worth it.
Iso-butane to iso-butane blends are reasonably safe as long as you don't overfill the canister (there are "head space" (unfilled volume) requirements to allow for gas expansion so that safe pressures are not exceeded. DO NOT exceed the original net fuel weight of the canister! Yes, this can happen, especially with a cold receiver canister and a warm inverted supply canister.
I would also caution people about the potential dangers of handling flammable gasses and the need for proper ventilation, static electricity suppression, etc. There's a LOT of stored energy in one of those little canisters - enough to end your life.
But people also need to be VERY knowledgeable and careful with some of the other related products listed on that amazon page, especially the adapters from propane cylinders to butane canisters. If you have a very accurate scale, and understand fuel vapor pressure curves, you could mix your own butane/propane blend. But iso-butane canisters aren't designed to handle the pressure created from pure propane gas.
There's also the potential safety issues of introducing water vapor internally into the canister when refilling it with an unpurged line/adapter assembly (leading to internal corrosion), how many fill/discharge cycles the canister and the valve are designed to withstand, the age, etc.
The EN 417:2012 standard governs iso-butane canister construction. The canisters are designed to be used with gasses not exceeding 13.2 bar (191 psi) at 50°C (122°F). Pure propane or a high percentage of propane would exceed that designed working pressure.
http://www.engineeringtoolbox.com/pr...ix-d_1043.html
http://standards.cen.eu/dyn/www/f?p=...7CCB7B59969669