I know of several people with one or two TKRs, and have heard of dozens more who have successfully finished their PT and are pain-free. Almost everyone agrees that it was worth it. My ortho doesn't want me to consider it until at least my mid-60s, primarily because I would be a candidate to wear it out after 15-20 years of backpacking and the like. The current success rate on second replacements is not nearly as high.