I hiked SOBO from Tellico River Rd. to Unicoi Gap. Brookshire Creek to Unicoi Gap kicked my butt but I still managed 16 miles through there, that was with a hip problem and a lot of pain. I think you'll do great. On day 1, you'll walk by an old ambulance and Dr. Rogers' house, described here in the 2nd paragraph
http://www.telliquah.com/roundhouse.htm.
Your 2nd day will be fast with some pretty scenery. Tellico River Rd. to Whigg Meadow is a gentle climb. Plan on having lunch at Whigg Meadow.
I will be hiking north of you around the same time. I hope to do Beech Gap to the tunnel.
Have a great trip!