I carry spray in the gsmnp. Most will say no, but it helps my piece of mind. I hike alone mostly so it's worth it for mine and my family's sanity.
However... I've found that (like stated before) getting hurt while out on the trail is more of a concern to me. This is coming from someone who has done many loops without seeing bears but has had real scares with slipping or falling and being injured alone without seeing anyone all day long and having to get myself off the trail/