Can you do it? Yes. Will it work for you? Maybe. It is very personal and situational, so testing is required and even if it works in some situations it may not work in all so be prepared to augment.
That being said, I've had good luck combining a 40°F down quilt with a 20°F synthetic on top. My thought was to move the condensation/frost point away from my down to avoid icing up on longer trips. What you have under you also really matters and I prefer to use a TR TrailPro on top of an inflatable like a TR XLite or BA QCore. Too much heat loss rolling around directly on the air mattress for my tastes. With this system, on the ground/snow, I can comfortably go past -10°F with extra clothing and hand warmers at the ready should things go wrong. Coldest I've taken it was -18°F and that was beyond comfort and time to pop hand warmers to make it til dawn.
Bottom line is test as much as you can and then be prepared for it not to work as well as it did in testing