Might sound a little unorthodox but I recently hiked 200+ miles without any socks and not any foot/skin irritation at all.
1st got a good pair of trail runners 1/2 larger to give my toes a little breathing/swelling room
2nd bought insoles with heal support tried 3 or 4 different ones till I found one good for me that kept heal stable
3rd used lock laces so my footwear never loosened while hiking
4th religiously used talc up to 3x a day in my footwear to keep feet dry and decrease any friction
5th Carried two pairs of Darn tough socks and only used in the rain. Put them on with talc inside only after my sockless foot got wet then after a few hours would change them out for the second dry pair.
6th Carried a few small pieces of duoderm and tegaderm just in case got blisters of skin tears on feet...never needed to use it.
7th dry clean feet in the pm used cushy and warm camp socks... applied real Pure Lanolin Anhydrous 9it's extremely thick and yellowish) to feet/heels every pm before bed